Dofetilide (Tikosyn) Considerations for Use*. US/FDA Special Notes. The patient must be registered to receive this drug; the hospital and pharmacy must. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Tikosyn (Dofetilide). (dofetilide) product monograph and refers you to more detailed information in read the patient package insert and reread it each time therapy is renewed in.
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Major Hypokalemia may dofetulide with administration of potassium-depleting drugs such as conivaptan, increasing the potential for dofetilide-induced torsade de pointes.
Electrolyte imbalances should be corrected prior to initiation of therapy. Doravirine; Lamivudine; Tenofovir disoproxil fumarate: Because of the potential for TdP, use of dofetilide with rilpivirine is contraindicated.
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Coadministration of conivaptan with dofetilide should be undertaken with extreme caution. Dofetilide plasma concentrations are correlated with the risk of drug-induced proarrhythmias.
Plasma dofetilide concentrations are correlated with the risk of drug-induced proarrhythmias. Following hawthorn administration to guinea pigs, the cardiac action potential duration is increased and the refractory period is prolonged.
Although extremely rare, torsade de pointes has been reported during post-marketing surveillance of norfloxacin. Potassium levels should be within the normal range prior and during administration of dofetilide. Because of the potential for TdP, use of dofetilide with pimozide is contraindicated. Concurrent exposure with dofetilide could increase the risk of dofetilide-induced proarrhythmias. In vitro, dofetilide is packags CYP3A4 substrate, although it has low affinity for this isoenzyme.
Severe Because of the potential for torsades de pointes TdPconcurrent dofetilid of dofetilide and chloroquine is contraindicated. Moderate Monitor for an increase in dofetilide-related adverse reactions, including QT prolongation, if coadministration with dalfopristin; quinupristin is necessary. Major Zafirlukast, a CYP 3A4 inhibitor, may increase plasma dofetilide concentrations with potential for dofetilide toxicity.
Dofetilide (Tikosyn) | Pharmacy
Rucaparib is a weak CYP3A4 inhibitor and dofetilide is a minor CYP3A4 substrate; however, because there is a linear relationship between dofetilide plasma concentration and QTc, concomitant administration of CYP3A4 inhibitors may increase the risk of arrhythmia torsade de pointes.
Dofetilide is a minor CYP3A4 substrate; however, because there is a linear relationship between dofetilide plasma concentration and QTc, concomitant administration of CYP3A4 inhibitors may increase the risk of arrhythmia torsade de pointes. During clinical trials of dofetilide, potassium concentrations were generally maintained between 3.
Refer to the step-by-step procedure above for determining the initial dosage of dofetilide. Severe Because of the potential for torsade de pointes TdPuse of sertraline with dofetilide is contraindicated. The maximal change in the QTc interval occurs approximately 5 to 10 hours following oral administration of gemifloxacin.
Your Name Your name is required. Because of the potential for TdP, use of lithium with dofetilide is contraindicated.
Dofetilide – GlobalRPH
According to the revised labeling for droperidol, any drug known to have potential to prolong the QT interval should not be coadministered with droperidol. Severe Concurrent use of dofetilide and lapatinib is contraindicated because of the potential for torsade de pointes TdP. Moderate Monitor for an increase in dofetilide-related adverse reactions, including QT prolongation, if coadministration with amlodipine is necessary.
Because buprenorphine has also been associated with QT prolongation and has a possible risk of dofetillde de pointes TdPcoadministration is contraindicated. Although there are no studies examining the effects of dronedarone in patients receiving other QT prolonging drugs, coadministration of such drugs may result in additive QT prolongation. Increased dofetilide plasma concentrations may be associated with proarrhythmias.
Dofetilide did not influence cardiac conduction velocity and sinus node function in a variety of studies in patients with or without structural heart disease.
Less than a 2-fold increase in the midazolam AUC is not considered apckage important. John’s Wort, Hypericum perforatum: The OBRA guidelines caution that antiarrhythmics can have serious adverse effects e. Severe Eribulin has been associated with QT prolongation.