Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.
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Discussion The results obtained from the study showed that the methanolic stem bark extract of Crossopteryx febrifuga possess anti-ulcerogenic activity in rats. The anti-ulcer effect of the extract may have been produced via enhanced prostaglandin synthesis, inhibition of leukotriene biosynthesis and decreased acid secretion. Group 1 rats served as the normal control received no treatment.
West African Plants
One hour after ethanol administration, the rats were sacrificed under diethyl ether anaesthesia. A saponin with anti-ulcerogenic effect from the flowers of Spartium junceum.
Anti-ulcer drugs of plant origin. Thus, illustrating the pharmacodynamic safety of the extract even in painful conditions associated with gastro-intestinal ulceration.
Physiological basis for drug treatment febifuga peptic ulcer: The method described by Salawu et al. Flavonoids have attracted the attention of many researchers because of their wide range of biological activities Lewis and Hanson,including antiulcer properties La Casa et al.
The extract profoundly antagonized the Piroxicam- induced ulceration in rats.
Crossopteryx – Wikipedia
The results obtained from the study showed that the methanolic stem bark extract of Crossopteryx febrifuga possess anti-ulcerogenic activity in rats.
Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. The resultant mixture was filtered using Whatman filter paper No.
Twenty four hours fasted rats were randomized into 6 groups of 5 rats each. Rubiaceae are widely used in Northern Nigeria in the therapeutic management of trypanosomiasis, malaria and painful inflammatory disorders.
Preparations of the tree is used traditionally for symptomatic relief of dry cough and for treatment of septic wounds, respiratory infections, fever, dysentery and pain. In northern Nigeria, the plant has been used for treatment of pain and malaria for many years and its efficacy has been established in our laboratory Salawu et al. Factors that may contribute to the protection of mucosa, such as mucus and bicarbonate secretion are dependent on gastric blood flow Guth et al.
Histopathology Ethanol caused destruction of several glandular areas and focal infiltration of inflammatory cells into the sub mucosa areas. These were then processed routinely and the tissues were embedded in paraffin wax.
Stimulation of rat gastric mucosal leukotriene C4 formation by ethanol and effect of gastric protective drugs. Pharmacological studies of Panacis japonici Rhizoma.
Preparation of the plant extract The stem bark was cleaned, air-dried for seven 7 days and crushed into coarse powder using a pestle and mortar.
Oxygen free radicals and lipid peroxidation Takeuchi et al. The number of deaths in each group within 24 h was recorded and the final LD 50 values were calculated as the geometric crossoptery of the highest nonlethal dose with no deaths and the lowest lethal dose where deaths occurred.
West African Plants – A Photo Guide – Crossopteryx febrifuga (Afzel. ex ) Benth.
Ethanol caused destruction of several glandular areas and focal infiltration of inflammatory cells into the sub mucosa areas. Cyclooxygenase-2 inhibition increases gastric tone and delays gastric emptying in rats. This article has been cited by crosspteryx articles in PMC. The oral median lethal dose LD 50 of febriguga methanolic extract was determined in rats orally using Lorke’s method with modifications.
The ulcer lesions were scored according to severity Larach and Malagelada, as follows: Preventive ratio PR defined as the degree of protection offered by a treatment against ulcer causing agent was calculated using the formula:.
Author information Copyright and License information Disclaimer. The authors are grateful to the management of National Institute for Pharmaceutical Research and Development for crossopteyrx of enabling environment and facilities used for the study. Table 1 Effect of Crossopteryx febrifuga crossopyeryx ethanol-induced gastric ulceration in rats. Pharmacological screening and toxicology. It is known that ethanol produces necrotic lesions in the gastric mucosa by its direct toxic effect, by fdbrifuga both secretion of bicarbonates and production of mucus Marhuenda et al.
The choice of models used for antiulcer evaluation is very appropriate because crossooteryx protocols undertaken in the rats are those mostly used for the evaluation of antiulcer agents and are reproducible. The rats were kept crossopterxy the same conditions and observed for signs of toxicity which include but not limited to paw-licking, stretching, respiratory distress and mortality for the first critical 4h and thereafter daily for 7 days.
In the stomach, prostaglandins is critical for the maintenance of gastric mucosal integrity, but the mechanism involved in the cytoprotective action of prostaglandins is still incompletely understood. Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the rats.
Previous studies using crude methanolic extract of C. Effect of the extract on piroxicam-induced gastric ulceration Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the febriduga. Materials and Methods Collection plant material Fresh stem bark of C. The products of the 5-lipoxygenase pathway may also play a key role in the development of ulcer induced by irritant agents such as ethanol Lange et al.
Table 2 Effect of the Crossopteryx febrifuga extract on piroxicam-induced gastric ulceration. Assessing African medicinal plants for efficacy and safety: